Ro 61-8048
Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC50 of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations[1].
Product Specifications
CAS Number
199666-03-0
UNSPSC
12352005
Hazard Statement
H302, H319
Target
KMO
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Ro-61-8048.html
Purity
99.76
Solubility
DMSO : ≥ 59 mg/mL
Smiles
O=S(C1=CC=C(OC)C(OC)=C1)(NC2=NC(C3=CC=CC([N+]([O-])=O)=C3)=CS2)=O
Molecular Formula
C17H15N3O6S2
Molecular Weight
421.45
Precautions
H302, H319
References & Citations
[1]S Röver, et al. Synthesis and biochemical evaluation of N- (4-phenylthiazol-2-yl) benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J Med Chem. 1997 Dec 19;40 (26) :4378-85.|[2]Melanie Hamann, et al. Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant. Eur J Pharmacol. 2008 May 31;586 (1-3) :156-9.|[3]AlbertoChiarugi, et al. Quinolinic acid formation in immune-activated mice: studies with (m-nitrobenzoyl) -alanine (mNBA) and 3,4-dimethoxy-[-N-4- (-3-nitrophenyl) thiazol-2yl]-benzenesulfonamide (Ro 61-8048), two potent and selective inhibitors of kynurenine hydroxylase. Neuropharmacology. Volume 38, Issue 8, August 1999, Pages 1225-1233.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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