Naphthol AS-E

Naphthol AS-E is a potent and cell-permeable inhibitor of KIX-KID interaction. Naphthol AS-E directly binds to the KIX domain of CBP (Kd:8.6 μM), blocks the interaction between the KIX domain and the KID domain of CREB with IC50 of 2.26 μM. Naphthol AS-E can be used for cancer research.

Product Specifications

CAS Number

[92-78-4]

UNSPSC

12352005

Hazard Statement

H317, H319

Target

Epigenetic Reader Domain; Histone Acetyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/naphthol-as-e.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

O=C(C1=C(O)C=C2C=CC=CC2=C1)NC3=CC=C(Cl)C=C3

Molecular Formula

C17H12ClNO2

Molecular Weight

297.74

Precautions

H317, H319

References & Citations

[1]Fuchun Xie, et al. Synthesis and Evaluation of an O-Aminated Naphthol AS-E as a Prodrug of CREB-mediated Gene Transcription Inhibition. Lett Org Chem. 2013 Jun;10 (5) :380-384.|[2]Bingbing X Li, et al. Discovery of a small-molecule inhibitor of the KIX-KID interaction. Chembiochem. 2009 Nov 23;10 (17) :2721-4.