ABBV-167
Product Specifications
UNSPSC Description
ABBV-167 is a phosphate proagent of the BCL-2 inhibitor venetoclax.
Target Antigen
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/abbv-167.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1(CCC(CN2CCN(CC2)C3=CC(OC4=CN(C5=NC=CC5=C4)COP(O)(O)=O)=C(C=C3)C(NS(=O)(C6=CC([N+]([O-])=O)=C(C=C6)NCC7CCOCC7)=O)=O)=C(C1)C8=CC=C(C=C8)Cl)C
Molecular Weight
978.45
References & Citations
[1]Salem AH, et al. Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers. Mol Cancer Ther. 2021 Jun;20(6):999-1008.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-142209/ABBV-167-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-142209/ABBV-167-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1351456-78-4
Available Sizes
Curated Selection
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