SKF-34288 (hydrochloride)

SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (Ki: 2-9 μM) . SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides[1][2].

Product Specifications

CAS Number

[320386-54-7]

Product Name Alternative

3-Mercaptopicolinic acid (hydrochloride) ; 3-MPA (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PEPCK

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/skf-34288-hydrochloride.html

Purity

98.61

Solubility

H2O : 5 mg/mL (ultrasonic)

Smiles

O=C(C1=NC=CC=C1S)O.[H]Cl

Molecular Formula

C6H6ClNO2S

Molecular Weight

191.64

Precautions

H302, H315, H319, H335

References & Citations

[1]Balan MD, et al. Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid. Biochemistry. 2015 Sep 29;54 (38) :5878-87. |[2]Bailey KJ, et al. Nitrogen recycling from the xylem in rice leaves: dependence upon metabolism and associated changes in xylem hydraulics. J Exp Bot. 2016 Apr;67 (9) :2901-11.|[3]Reverte M, et al. Changes in plasma glucose and lactate evoked by alpha and beta 2-adrenoceptor stimulation in conscious fasted rabbits. Fundam Clin Pharmacol. 1991;5 (8) :663-76. |[4]Brearley MC, et al. The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells. Sci Rep. 2020 Dec 17;10 (1) :22177. |[5]Ohmori H, et al. The Production of a Rat Model That Inhibits Phosphoenolpyruvate Carboxykinase (PEPCK), a Rate-Limiting Enzyme of Hepatic Gluconeogenesis. Adv Exp Med Biol. 2019;1155:113-118. |[6]DiTullio NW, et al. 3-mercaptopicolinic acid, an inhibitor of gluconeogenesis. Biochem J. 1974 Mar;138 (3) :387-94.