VU0238441

VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively[1][2].

Product Specifications

CAS Number

[85511-68-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu0238441.html

Purity

99.87

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1N(CC2=CC=C(C(F)(F)F)C=C2)C3=C(C=CC=C3Cl)C1=O

Molecular Formula

C16H9ClF3NO2

Molecular Weight

339.70

Precautions

H302, H315, H319, H335

References & Citations

[1]Thomas M Bridges, et al. Chemical lead optimization of a pan G (q) mAChR M (1), M (3), M (5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M (5) PAM. Bioorg Med Chem Lett. 2010 Jan 15;20 (2) :558-62.|[2]Thomas M Bridges, et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem. 2009 Jun 11;52 (11) :3445-8.