6-Aminocaproic acid

6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

Product Specifications

CAS Number

[60-32-2]

Product Name Alternative

EACA; Epsilon-Amino-n-caproic Acid; 6-Aminohexanoic acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

PAI-1

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/6-aminocaproic-acid.html

Purity

99.86

Solubility

DMSO : < 1 mg/mL|H2O : ≥ 50 mg/mL

Smiles

O=C(O)CCCCCN

Molecular Formula

C6H13NO2

Molecular Weight

131.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Griffin JD, et, al. Epsilon-aminocaproic acid (EACA) . Semin Thromb Hemost. Summer 1978;5 (1) :27-40.|[2]Kaye S, et, al. EFFECT OF ε-AMINOCAPROIC ACID ON FIBRINOLYSIS IN PLASMA OF ASIAN ELEPHANTS (ELEPHAS MAXIMUS) . J Zoo Wildl Med. 2016 Jun;47 (2) :397-404.|[3]Brown JC, et, al. Effect of aminocaproic acid on clot strength and clot lysis of canine blood determined by use of an in vitro model of hyperfibrinolysis. Am J Vet Res. 2016 Nov;77 (11) :1258-1265.|[4]Hu Q, et al. 6-Aminocaproic acid as a linker to improve near-infrared fluorescence imaging and photothermal cancer therapy of PEGylated indocyanine green. Colloids Surf B Biointerfaces. 2021 Jan;197:111372.