Syringaresinol

Syringaresinol is a lignan-type phytochemical with anti-inflammatory activities. Syringaresinol inhibits the NF-κB and AKT signaling pathway in IL-1β-activated mouse chondrocytes. Syringaresinol increases phosphorylation of AMPK, eNOS, and intracellular Ca2+ levels in HUVECs. Syringaresinol attenuates osteoarthritis progression in mice with Destabilization of the Medial Meniscus (DMM) -induced osteoarthritis. Syringaresinol can be used for the study of osteoarthritis (OA) [1][2].

Product Specifications

CAS Number

[487-35-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Akt; AMPK; Calcium Channel; NF-κB; NO Synthase

Type

Natural Products

Related Pathways

Epigenetics; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/syringaresinol.html

Purity

99.66

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=C(OC)C=C(C2OCC3C2COC3C4=CC(OC)=C(O)C(OC)=C4)C=C1OC

Molecular Formula

C22H26O8

Molecular Weight

418.44

Precautions

H302, H315, H319

References & Citations

[1]Chung BH, et al. Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase. Exp Mol Med. 2012 Mar 31;44 (3) :191-201. |[2]Wang X, et al. Syringaresinol attenuates osteoarthritis via regulating the NF-κB pathway. Int Immunopharmacol. 2023 May;118:109982.