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SNIPER(ABL)-020

Product Specifications

UNSPSC Description

SNIPER(ABL)-020, conjugating Dasatinib (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein[1].

Target Antigen

Bcr-Abl; SNIPERs

Type

Reference compound

Related Pathways

PROTAC;Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sniper-abl-020.html

Purity

99.79

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(C(COCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@@H](CC5=CC=CC=C5)N)=O)=O)=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1

Molecular Weight

923.52

References & Citations

[1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-111872/SNIPER-ABL-020-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-111872/SNIPER-ABL-020-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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