SNIPER (ABL) -020
SNIPER (ABL) -020, conjugating Dasatinib (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein[1].
Product Specifications
UNSPSC
12352005
Target
Bcr-Abl; SNIPERs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sniper-abl-020.html
Purity
99.79
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(C(COCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@@H](CC5=CC=CC=C5)N)=O)=O)=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1
Molecular Formula
C44H59ClN10O8S
Molecular Weight
923.52
References & Citations
[1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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