Lamotrigine-d3

Lamotrigine-d3 is the deuterium labeled Lamotrigine[1]. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[2][3].

Product Specifications

CAS Number

[1132746-94-1]

Product Name Alternative

LTG-d3; BW430C-d3

UNSPSC

12352005

Hazard Statement

H301, H319, H336, H361, H362, H410

Target

Autophagy; Sodium Channel

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

98.93

Solubility

10 mM in DMSO|DMSO : ≥ 10mg/mL

Smiles

NC1=NC(N)=C(C2=C(Cl)C(Cl)=C([2H])C([2H])=C2[2H])N=N1

Molecular Formula

C9H4D3Cl2N5

Molecular Weight

259.11

Precautions

H301, H319, H336, H361, H362, H410

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]M J Leach, et al. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. Sep-Oct 1986;27 (5) :490-7.|[3]Damianka P Getova, et al. A study of the effects of lamotrigine on mice using two convulsive tests. Folia Med (Plovdiv) . Apr-Jun 201153 (2) :57-62.