SMARCA-BD ligand 1 for PROTAC
SMARCA-BD ligand 1 for PROTAC is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC[1].
Product Specifications
CAS Number
[1997319-92-2]
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; SWI/SNF Complex
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-4-binding-moiety-1.html
Purity
99.07
Solubility
DMSO : 33.33 mg/mL (ultrasonic; adjust pH to 6 with 1 M HCl)
Smiles
OC1=CC=CC=C1C2=NN=C(N)C(N3CCNCC3)=C2
Molecular Formula
C14H17N5O
Molecular Weight
271.32
References & Citations
[1]Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15 (7) :672-680.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Protein Polybromo-1; SMARCA2; SMARCA4
Available Sizes
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