2',5'-Dideoxyadenosine

2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart[1][2].

Product Specifications

CAS Number

[6698-26-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adenylate Cyclase; Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-5-dideoxyadenosine.html

Purity

99.86

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

C[C@@H]1[C@H](C[C@H](N2C=NC3=C(N=CN=C32)N)O1)O

Molecular Formula

C10H13N5O2

Molecular Weight

235.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Bushfield M, et al. Tissue levels, source, and regulation of 3'-AMP: an intracellular inhibitor of adenylyl cyclases. Mol Pharmacol. 1990 Dec;38 (6) :848-53.|[2]Hartmann M, et al. Isoproterenol antagonistic effect of 2',5'-dideoxyadenosine in the isolated perfused guinea-pig heart. J Mol Cell Cardiol. 1993 Mar;25 (3) :331-8.|[3]Zhao LX, et al. M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt. FASEB J. 2019 May;33 (5) :6622-6631.|[4]Leme Tdos S, et al. Role of prostaglandin/cAMP pathway in the diuretic and hypotensive effects of purified fraction of Maytenus ilicifolia Mart ex Reissek (Celastraceae) . J Ethnopharmacol. 2013 Oct 28;150 (1) :154-61.