(S, R, S) -AHPC-C6-PEG3-C4-Cl

(S, R, S) -AHPC-C6-PEG3-C4-Cl (VH032-C6-PEG3-C4-Cl) is a conjugate of ligands for E3 and 20-atom-length linker. The connector of linker is Halogen group. (S, R, S) -AHPC-C6-PEG3-C4-Cl incorporates the (S, R, S) -AHPC based VHL ligand and an alkyl/ether-based linker. (S, R, S) -AHPC-C6-PEG3-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

Product Specifications

CAS Number

[1835705-55-9]

Product Name Alternative

VH032-C6-PEG3-C4-Cl; VHL Ligand-Linker Conjugates 12; E3 ligase Ligand-Linker Conjugates 8

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/E3 ligase_Ligand-Linker_Conjugates_8.html

Purity

97.01

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCCOCCOCCOCCCCCCCl)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2

Molecular Formula

C38H59ClN4O7S

Molecular Weight

751.42

Precautions

H302, H315, H319, H335

References & Citations

[1]US 20170121321 A1|[2]Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55 (2) :807-10.