T0070907

T0070907 is a potent PPARγ antagonist with a Ki of 1 nM.

Product Specifications

CAS Number

[313516-66-4]

UNSPSC

12352005

Hazard Statement

H302, H319

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/t0070907.html

Purity

99.98

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL

Smiles

ClC1=C(C=C(C=C1)[N+]([O-])=O)C(NC2=CC=NC=C2)=O

Molecular Formula

C12H8ClN3O3

Molecular Weight

277.66

Precautions

H302, H319

References & Citations

[1]An Z, et al. T0070907 inhibits repair of radiation-induced DNA damage by targeting RAD51. Toxicol In Vitro. 2016 Dec;37:1-8|[2]An Z, et al. T0070907, a PPAR γ inhibitor, induced G2/M arrest enhances the effect of radiation in human cervical cancer cells through mitotic catastrophe. Reprod Sci. 2014 Nov;21 (11) :1352-61.|[3]Kawahara A, et al. Peroxisome proliferator-activated receptor γ (PPARγ) -independent specific cytotoxicity against immature adipocytes induced by PPARγ antagonist T0070907. Biol Pharm Bull. 2013;36 (9) :1428-34|[4]Lee G, et al. T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J Biol Chem. 2002 May 31;277 (22) :19649-57. Epub 2002 Mar 4