24R-Calcipotriol

24R-Calcipotriol (PRI 2202) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. IC50 value: Target: Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

Product Specifications

CAS Number

[112827-99-3]

Product Name Alternative

PRI 2202; Impurity D of Calcipotriol

UNSPSC

12352211

Hazard Statement

H300, H311, H331, H373

Target

VD/VDR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/24R-Calcipotriol.html

Purity

95.64

Solubility

10 mM in DMSO

Smiles

O[C@H]1C[C@H](O)C(/C(C1)=C\C=C2[C@]3([H])CC[C@H]([C@H](C)/C=C/[C@@H](C4CC4)O)[C@@]3(C)CCC\2)=C

Molecular Formula

C27H40O3

Molecular Weight

412.60

Precautions

H300, H311, H331, H373

References & Citations

[1]Gocek, Elzbieta; Kielbinski, Marek; Baurska, Hanna et al. Different susceptibilities to 1,25-dihydroxyvitamin D3-induced differentiation of AML cells carrying various mutations. Leukemia Research (2010), 34 (5), 649-657.|[2]Gocek, Elzbieta; Kielbinski, Marek; Wylob, Paulina et al. Side-chain modified vitamin D analogs induce rapid accumulation of VDR in the cell nuclei proportionately to their differentiation-inducing potential. Steroids (2008), 73 (14), 1359-1366.|[3]Wietrzyk, Joanna; Nevozhay, Dmitry; Filip, Beata et al. The antitumor effect of lowered doses of cytostatics combined with new analogs of vitamin D in mice. Anticancer Research (2007), 27 (5A), 3387-3398.|[4]Wietrzyk, Joanna; Chodynski, Michal; Fitak, Hanna et al. Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anti-Cancer Drugs (2007), 18 (4), 447-457.