YB-0158

YB-0158 (Wnt pathway inhibitor 2) is a reverse-turn peptidomimetic and a potent colorectal cancer stem cell (CSC) targeting agent. YB-0158 disrupts Sam68-Src interactions and induces apoptosis in CRC cells. Anti-cancer activities[1].

Product Specifications

CAS Number

[1144043-83-3]

Product Name Alternative

Wnt pathway inhibitor 2

UNSPSC

12352005

Target

Apoptosis; Wnt

Type

Reference compound

Related Pathways

Apoptosis; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/yb-0158.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; adjust pH to 1 with 1M HCl)

Smiles

O=P(O[Na])(O[Na])OC1=CC=C(C[C@H]2C(N(CC3=CC=CC4=C3NN=C4)C[C@H](N(C(NCC5=CC=CC=C5)=O)N(CC=C)C6)N2C6=O)=O)C=C1

Molecular Formula

C32H32N7Na2O7P

Molecular Weight

703.59

References & Citations

[1]Masibag AN, Bergin CJ, Haebe JR, et al. Pharmacological targeting of Sam68 functions in colorectal cancer stem cells. iScience. 2021;24 (12) :103442.