Pyrroloquinoline quinone

Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function[1][2].

Product Specifications

CAS Number

[72909-34-3]

Product Name Alternative

PQQ; Methoxatin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pyrroloquinoline-quinone.html

Purity

99.82

Solubility

1 M NaOH : 33.33 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C(N1)=CC(C2=O)=C1C3=C(N=C(C(O)=O)C=C3C(O)=O)C2=O)O

Molecular Formula

C14H6N2O8

Molecular Weight

330.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Moog RS, et al. Evidence for methoxatin (pyrroloquinolinequinone) as the cofactor in bovine plasma amine oxidase from resonance Raman spectroscopy. Proc Natl Acad Sci U S A. 1986 Nov;83 (22) :8435-9.|[2]Bishop A, et al. Methoxatin (PQQ) in guinea-pig neutrophils. Free Radic Biol Med. 1994 Oct;17 (4) :311-20.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Human Endogenous Metabolite; Microbial Metabolite

Citation 01

Antioxidants (Basel) . 2025 Jan 16;14 (1) :102.|Biosens Bioelectron. 2024 Apr 15:250:116049.|Antioxidants (Basel) . 2024 Jan 15;13 (1) :104.|J Agric Food Chem. 2024 Sep 25;72 (38) :20944-20958.|J Chromatogr B Analyt Technol Biomed Life Sci. 2025 Apr 15:1256:124559.