A66
A66 is a highly specific and selective p110α inhibitor with an IC50 of 32 nM.
Product Specifications
CAS Number
1166227-08-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/A66.html
Purity
99.73
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C)(C1=NC(C2=C(N=C(S2)NC(N3[C@@H](CCC3)C(N)=O)=O)C)=CS1)C
Molecular Formula
C17H23N5O2S2
Molecular Weight
393.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Jamieson S, et al. A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem J, 2011, 438 (1), 53-62.|[2]Sun M, et al. Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha. Proc Natl Acad Sci U S A, 2010, 107 (35), 15547-15552.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3KC2β; PI3Kα; PI3Kγ
Available Sizes
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