A66

A66 is a highly specific and selective p110α inhibitor with an IC50 of 32 nM.

Product Specifications

CAS Number

[1166227-08-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/A66.html

Purity

99.73

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C)(C1=NC(C2=C(N=C(S2)NC(N3[C@@H](CCC3)C(N)=O)=O)C)=CS1)C

Molecular Formula

C17H23N5O2S2

Molecular Weight

393.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Jamieson S, et al. A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem J, 2011, 438 (1), 53-62.|[2]Sun M, et al. Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha. Proc Natl Acad Sci U S A, 2010, 107 (35), 15547-15552.