Muscone

Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate[1].

Product Specifications

CAS Number

[541-91-3]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Interleukin Related; NF-κB; NOD-like Receptor (NLR) ; P-glycoprotein; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/muscone.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1CC(C)CCCCCCCCCCCC1

Molecular Formula

C16H30O

Molecular Weight

238.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Du Y, et al. Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome. Am J Transl Res. 2018 Dec 15;10 (12) :4235-4246.