PF-4989216
PF-4989216 is a potent and selective PI3Kα inhibitor with a Ki of 0.6 nM.
Product Specifications
CAS Number
[1276553-09-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; PI3K
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PF-4989216.html
Concentration
10mM
Purity
99.38
Solubility
DMSO : ≥ 29 mg/mL
Smiles
N#CC1=C(N2CCOCC2)SC(C3=NC=NN3)=C1C4=CC=C(C#N)C=C4F
Molecular Formula
C18H13FN6OS
Molecular Weight
380.40
Precautions
H302, H315, H319
References & Citations
[1]Liu KK, et al. Highly Selective and Potent Thiophenes as PI3K Inhibitors with Oral Antitumor Activity. ACS Med Chem Lett. 2011 Sep 19;2 (11) :809-813.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα
Available Sizes
Curated Selection
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