ER-000444793
ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening. ER-000444793 inhibits mPTP with an IC50 of 2.8 μM.
Product Specifications
CAS Number
[792957-74-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ER-000444793.html
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1=C(CC2=CC=CC=C2)C=CC=C1)C(C3=CC=CC=C3N4)=CC4=O
Molecular Formula
C23H18N2O2
Molecular Weight
354.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Briston T, et al. Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria. Sci Rep. 2016 Nov 25;6:37798.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
GTR15242258 1 Vial
Lentiviral mouse Bicral shRNA (UAS) - Lentiviral mouse Bicral shRNA (UAS, iRFP) (25)
Ask
View Details 302835-Biotin 100 µL
VAC14 (Protein VAC14 Homolog, Tax1-Binding Protein 2, VAC14, TAX1BP2, TRX) (Biotin) discontinued
Ask
View Details 
031605-ML550 100 µL
ADAM23, CT (ADAM23, MDC3, Disintegrin and metalloproteinase domain-containing protein 23, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MaxLight 550) discontinued
Ask
View Details 