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[10]-Shogaol (Standard)

[10]-Shogaol (Standard) is the analytical standard of [10]-Shogaol. This product is intended for research and analytical applications. [10]-Shogaol is an orally active antioxidant. [10]-Shogaol can be extracted from ginger (Zingiber officinale). [10]-Shogaol1 inhibits COX-2 with an IC50 value of 7.5 μM. [10]-Shogaol inhibits the production of proinflammatory cytokines (IL-1β, IL-6). [10]-Shogaol inhibits NF-κB phosphorylation. [10]-Shogaol has anti-inflammatory effects. [10]-Shogaol has anticancer effects against Docetaxel (HY-B0011) -resistant prostate cancer. [10]-Shogaol exhibits larvicidal activity against L5 larvae of Angiostrongylus cantonensis[1][2][3][4][5].

Product Specifications

CAS Number

36752-54-2

UNSPSC

12352005

Target

COX; Interleukin Related; NF-κB; Parasite; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Immunology/Inflammation; NF-κB; Others

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/10-shogaol-standard.html

Smiles

CCCCCCCCC/C=C/C(CCC1=CC=C(O)C(OC)=C1)=O

Molecular Formula

C21H32O3

Molecular Weight

332.48

References & Citations

[1]Chen CY, et al. 10-Shogaol, an antioxidant from Zingiber officinale for skin cell proliferation and migration enhancer. Int J Mol Sci. 2012;13 (2) :1762-77.|[2]van Breemen RB, et al. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale) . Fitoterapia. 2011 Jan;82 (1) :38-43.|[3]Liu CM, et al. Ginger Phytochemicals Inhibit Cell Growth and Modulate Drug Resistance Factors in Docetaxel Resistant Prostate Cancer Cell. Molecules. 2017 Sep 5;22 (9) . pii: E1477.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Isoform

COX-2; IL-1; IL-6

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