Camptothecin-20 (S) -O-propionate
Camptothecin-20 (S) -O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20 (S) -O-propionate (CZ48) is a topoisomerase-Ι inhibitor[1][2][3].
Product Specifications
CAS Number
[194414-69-2]
Product Name Alternative
Camptothecin-20-O-propionate
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/camptothecin-20-s-o-propionate.html
Purity
99.55
Solubility
DMSO : 9.09 mg/mL (ultrasonic)
Smiles
O=C1[C@](CC)(C2=C(C(N3CC4=CC5=CC=CC=C5N=C4C3=C2)=O)CO1)OC(CC)=O
Molecular Formula
C23H20N2O5
Molecular Weight
404.42
References & Citations
[1]Xing Liu, et al. Correlation between the sensitivity of tumors to treatment with CZ48 and local concentrations of the active metabolite CPT within the tumors. Biomed Rep. 2013 Mar;1 (2) :202-206.|[2]Zhisong Cao, et al. Crystalline camptothecin-20 (S) -O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69 (11) :4742-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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