Camptothecin-20 (S) -O-propionate

Camptothecin-20 (S) -O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20 (S) -O-propionate (CZ48) is a topoisomerase-Ι inhibitor[1][2][3].

Product Specifications

CAS Number

[194414-69-2]

Product Name Alternative

Camptothecin-20-O-propionate

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/camptothecin-20-s-o-propionate.html

Purity

99.55

Solubility

DMSO : 9.09 mg/mL (ultrasonic)

Smiles

O=C1[C@](CC)(C2=C(C(N3CC4=CC5=CC=CC=C5N=C4C3=C2)=O)CO1)OC(CC)=O

Molecular Formula

C23H20N2O5

Molecular Weight

404.42

References & Citations

[1]Xing Liu, et al. Correlation between the sensitivity of tumors to treatment with CZ48 and local concentrations of the active metabolite CPT within the tumors. Biomed Rep. 2013 Mar;1 (2) :202-206.|[2]Zhisong Cao, et al. Crystalline camptothecin-20 (S) -O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69 (11) :4742-9.