CATB (Cleaved-Asn126) rabbit pAb

Catalytic activity: Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides. function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. similarity: Belongs to the peptidase C1 family. subcellular location: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. subunit: Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.

Product Specifications

Background

Catalytic activity:Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L) . In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides., function:Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis., similarity:Belongs to the peptidase C1 family., subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV., subunit:Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.

UniProt

P07858

Swiss Prot

P07858

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from human CATB (Cleaved-Asn126)

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:1000-2000 ELISA 1:5000-20000

Molecular Weight

15 37kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

15 37kD

Fragment

IgG

Subcellular Location

Lysosome . Melanosome . Secreted, extracellular space . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065) . Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity) . .