Fmoc-leucine

Fmoc-Leucine (N-FMOC-leucine) is an anti-inflammatory agent that not only promotes extracellular Ca2+ influx but also facilitates intracellular Ca2+ release. Fmoc-Leucine is a selective ligand for PPARγ (Ki = 15 μM), exhibiting insulin-sensitizing effects but with weak fatogenic activity. Fmoc-Leucine exhibits unique self-assembly properties and can form transient gels, stable gels, or crystals/2D sheets through different pathways. Fmoc-Leucine can be used in the research of diabetes, colitis, and bladder cancer[1][2][3][4].

Product Specifications

CAS Number

[35661-60-0]

Product Name Alternative

N-FMOC-leucine; NPC 15199; NSC 334290

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel; Lipase; PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Inflammation/Immunology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/fmoc-leucine.html

Purity

99.91

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C)C[C@@H](C(O)=O)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Molecular Formula

C21H23NO4

Molecular Weight

353.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Rocchi S, et al. A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell. 2001 Oct;8 (4) :737-47. |[2]Paul S, et al. Complex Pathways Drive Pluripotent Fmoc-Leucine Self-Assemblies. Angew Chem Int Ed Engl. 2024 Sep 9;63 (37) :e202406220.|[3]Jan CR, Yu CC, Huang JK. NPC-15199, a novel anti-inflammatory agent, mobilizes intracellular Ca2+ in bladder female transitional carcinoma (BFTC) cells. Chin J Physiol. 2000 Mar 31;43 (1) :29-33.|[4]Jan CR, et al. Effect of NPC-15199 on Ca2+ levels in renal tubular cells. Chin J Physiol. 2002 Sep 30;45 (3) :117-22. Erratum in: Chin J Physiol. 2003 Dec 31;45 (4) :200.