Canine GITR / TNFRSF18 Protein, His Tag

Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Product Specifications

Background

Specifications

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.8 kDa. The protein migrates as 20-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

D7F619-1

Expression Region

Gly 23 - Pro 154

Host

HEK293

Target

GITR

Conjugation

Unconjugated

Tag

C-10xHis

Source

Canine

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

90%

Bioactivity

Immobilized Canine GITR, His Tag (Cat. No. GIR-C52H6) at 2 μg/mL (100 μL/well) can bind Human GITR Ligand, Fc Tag (Cat. No. GIL-H526a) with a linear range of 2-40 ng/mL (QC tested).