1-Stearoyl-2-15 (S) -Hpete-Sn-Glycero-3-Pe
1-Stearoyl-2-15 (S) -HpETE-sn-glycero-3-Pe is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15 (S) -HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-Pe (SAPE) by 15-lipoxygenase (15-LO) . 1-Stearoyl-2-15 (S) -HpETE-sn-glycero-3-Pe (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.
Product Specifications
CAS Number
[154436-49-4]
Product Name Alternative
1-Stearoyl-2-15 (S) -HpETE-sn-glycero-3-phosphoethanolamine; 15 (S) -HpETE-SAPE; 15 (S) -hydroperoxyeicostetraenoic acid-SAPE
UNSPSC
12352211
Hazard Statement
H225, H319
Target
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/1-stearoyl-2-15-s-hpete-sn-glycero-3-pe.html
Concentration
624.96 μM * 100 μL in Ethanol
Purity
95.1
Smiles
O=C(CCC/C=C\C/C=C\C/C=C\C=C\[C@@H](OO)CCCCC)O[C@H](COC(CCCCCCCCCCCCCCCCC)=O)COP(OCCN)(O)=O
Molecular Formula
C43H78NO10P
Molecular Weight
800.05
Precautions
H225, H319
References & Citations
[1]Kagan, et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat. Chem. Biol. 13 (1), 81-90 (2017) .
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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