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AL-611

AL-611 is an HCV NS5B polymerase inhibitor (EC50 = 5 nM) .

Product Specifications

CAS Number

[2481279-61-0]

UNSPSC

12352005

Target

HCV Protease

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/al-611.html

Purity

99.93

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

C[C@@]1([C@](O[C@@](F)([C@H]1O)CO[P@](OC2=CC=CC=C2)(N[C@@H](C)C(OC(C)C)=O)=O)([H])N3C4=NC(N)=NC(OCC)=C4N=C3)F

Molecular Formula

C25H33F2N6O8P

Molecular Weight

614.54

References & Citations

[1]Wang G, et al. Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C. J Med Chem. 2020 Sep 24;63 (18) :10380-10395.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Available Sizes

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