CRT0044876

CRT0044876 is a potent and selective apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor (IC50=~3 μM) . CRT0044876 inhibits the AP endonuclease, 3′-phosphodiesterase and 3′-phosphatase activities of APE1, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds[1].

Product Specifications

CAS Number

[6960-45-8]

UNSPSC

12352005

Hazard Statement

H319, H334

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/crt0044876.html

Purity

98.88

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

Smiles

O=C(C(N1)=CC2=C1C([N+]([O-])=O)=CC=C2)O

Molecular Formula

C9H6N2O4

Molecular Weight

206.16

Precautions

H319, H334

References & Citations

[1]Madhusudan S, et al. Isolation of a small molecule inhibitor of DNA base excision repair. Nucleic Acids Res. 2005;33 (15) :4711-4724. Published 2005 Aug 19.