S55746 (hydrochloride)
S55746 hydrochloride (BCL201 hydrochloride) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 hydrochloride (BCL201 hydrochloride) has antitumor activity with low toxicity[1].
Product Specifications
CAS Number
[1448525-91-4]
Product Name Alternative
BCL201 (hydrochloride)
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/S55746_hydrochloride.html
Concentration
10mM
Purity
99.66
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(C1=C2CCCCN2C(C3=C(C(N4CC5=C(C=CC=C5)C[C@H]4CN6CCOCC6)=O)C=C(OCO7)C7=C3)=C1)N(C8=CC=C(O)C=C8)C9=CC=CC=C9.Cl
Molecular Formula
C43H43ClN4O6
Molecular Weight
747.28
References & Citations
[1]Casara P, et al. S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth. Oncotarget. 2018 Apr 13;9 (28) :20075-20088.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Bcl-2; Bcl-xL
Available Sizes
Curated Selection
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