AR7

AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy[1].

Product Specifications

CAS Number

[80306-38-3]

UNSPSC

12352005

Hazard Statement

H410

Target

RAR/RXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/AR7.html

Concentration

10mM

Purity

99.38

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1

Molecular Formula

C15H12ClNO

Molecular Weight

257.71

Precautions

H410

References & Citations

[1]Anguiano J, et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat Chem Biol. 2013 Jun;9 (6) :374-82.|[2]Philip Wing-Lok Ho, et al. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA) . Autophagy. 2020 Feb;16 (2) :347-370.|[3]Mathieu Bourdenx, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021 May 13;184 (10) :2696-2714.e25.