What is the catalog number for AR7?

The catalog number for AR7 is HY-101106.

What sizes are available for AR7?

AR7 is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 25 mg, 50 mg, 100 mg.

How many pack sizes does AR7 come in?

AR7 is available in 6 different pack sizes.

AR7 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures AR7?

AR7 is manufactured by QuantiMol.

What is the estimated delivery time for AR7?

Estimated delivery time for AR7 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for AR7?

The safety data sheet for AR7 is available here: http://file.medchemexpress.com/batch_PDF/HY-101106/AR7-SDS-MedChemExpress.pdf.

AR7

AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy[1].

Product Specifications

CAS Number

80306-38-3

UNSPSC

12352005

Hazard Statement

H410

Target

RAR/RXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/AR7.html

Concentration

10mM

Purity

99.38

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1

Molecular Formula

C15H12ClNO

Molecular Weight

257.71

Precautions

H410

References & Citations

[1]Anguiano J, et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat Chem Biol. 2013 Jun;9 (6) :374-82.|[2]Philip Wing-Lok Ho, et al. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA) . Autophagy. 2020 Feb;16 (2) :347-370.|[3]Mathieu Bourdenx, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021 May 13;184 (10) :2696-2714.e25.