Narciclasine
Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
Product Specifications
CAS Number
29477-83-6
Product Name Alternative
Lycoricidinol
UNSPSC
12352005
Hazard Statement
H302, H340
Target
ROCK
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Narciclasine.html
Purity
99.88
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C1N[C@@]2([H])[C@H](O)[C@H](O)[C@@H](O)C=C2C3=C1C(O)=C4C(OCO4)=C3
Molecular Formula
C14H13NO7
Molecular Weight
307.26
Precautions
H302, H340
References & Citations
[1]Lefranc F, et al. Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells. Mol Cancer Ther. 2009 Jul;8 (7) :1739-50.|[2]Wahyuni DS, et al. The use of bio-guided fractionation to explore the use of leftover biomass in Dutch flower bulb production as allelochemicals against weeds. Molecules. 2013 Apr 17;18 (4) :4510-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
ROCK
Available Sizes
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