Narciclasine

Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

Product Specifications

CAS Number

[29477-83-6]

Product Name Alternative

Lycoricidinol

UNSPSC

12352005

Hazard Statement

H302, H340

Target

ROCK

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Narciclasine.html

Purity

99.88

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C1N[C@@]2([H])[C@H](O)[C@H](O)[C@@H](O)C=C2C3=C1C(O)=C4C(OCO4)=C3

Molecular Formula

C14H13NO7

Molecular Weight

307.26

Precautions

H302, H340

References & Citations

[1]Lefranc F, et al. Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells. Mol Cancer Ther. 2009 Jul;8 (7) :1739-50.|[2]Wahyuni DS, et al. The use of bio-guided fractionation to explore the use of leftover biomass in Dutch flower bulb production as allelochemicals against weeds. Molecules. 2013 Apr 17;18 (4) :4510-25.