Tyrosine kinase inhibitor
Product Specifications
UNSPSC Description
Tyrosine kinase inhibitor is a potent tyrosine kinase inhibitor.
Target Antigen
c-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Tyrosine-kinase-inhibitor.html
Purity
99.88
Solubility
DMSO : ≥ 46 mg/mL
Smiles
O=C(NC1=CC=C(C=C1)F)C2(CC2)C(NC3=CC=C(C=C3)OC4=C5C(NC(C(NCCN6CCOCC6)=O)=C5)=NC=C4)=O
Molecular Weight
586.61
References & Citations
[1]Inoue T, et al. 
Two cases of gastrointestinal perforation after radiotherapy in patients receiving tyrosine kinase inhibitor for advanced renal cell carcinoma.
World J Surg Oncol. 2012 Aug 20;10(1):167.|[2]Bowen JM, et al. 
Development of a rat model of oral small molecule receptor tyrosine kinase inhibitor-induced diarrhea.
Cancer Biol Ther. 2012 Nov 1;13(13).|[3]Sun FK, et al. 
Multi-targeted tyrosine kinase inhibitor sunitinib: a novel strategy for sporadic malignant pheochromocytoma.
Chin Med J (Engl). 2012 Jun;125(12):2231-4.|[4]Thamm DH.
Tyrosine kinase inhibitor special issue.
Vet Comp Oncol. 2012 Sep;10(3):161-2. doi: 10.1111/j.1476-5829.2012.00339.x.|[5]Eriksson A, et al. 
The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia.
Blood Cancer J. 2012 Aug 3;2:e81. doi: 10.1038/bcj.2012.28.|[6]Paul MK, et al. Tyrosine kinase - Role and significance in Cancer. Int J Med Sci. 2004;1(2):101-115.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10421/Tyrosine-kinase-inhibitor-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10421/Tyrosine-kinase-inhibitor-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1021950-26-4
Available Sizes
Curated Selection
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