Tyrosine kinase inhibitor

Tyrosine kinase inhibitor is a potent tyrosine kinase inhibitor.

Product Specifications

CAS Number

[1021950-26-4]

UNSPSC

12352005

Target

C-Met/HGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Tyrosine-kinase-inhibitor.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : ≥ 46 mg/mL

Smiles

O=C(NC1=CC=C(C=C1)F)C2(CC2)C(NC3=CC=C(C=C3)OC4=C5C(NC(C(NCCN6CCOCC6)=O)=C5)=NC=C4)=O

Molecular Formula

C31H31FN6O5

Molecular Weight

586.61

References & Citations

[1]Inoue T, et al.  Two cases of gastrointestinal perforation after radiotherapy in patients receiving tyrosine kinase inhibitor for advanced renal cell carcinoma. World J Surg Oncol. 2012 Aug 20;10 (1) :167.|[2]Bowen JM, et al.  Development of a rat model of oral small molecule receptor tyrosine kinase inhibitor-induced diarrhea. Cancer Biol Ther. 2012 Nov 1;13 (13) .|[3]Sun FK, et al.  Multi-targeted tyrosine kinase inhibitor sunitinib: a novel strategy for sporadic malignant pheochromocytoma. Chin Med J (Engl) . 2012 Jun;125 (12) :2231-4.|[4]Thamm DH. Tyrosine kinase inhibitor special issue. Vet Comp Oncol. 2012 Sep;10 (3) :161-2. doi: 10.1111/j.1476-5829.2012.00339.x.|[5]Eriksson A, et al.  The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia. Blood Cancer J. 2012 Aug 3;2:e81. doi: 10.1038/bcj.2012.28.|[6]Paul MK, et al. Tyrosine kinase - Role and significance in Cancer. Int J Med Sci. 2004;1 (2) :101-115.