Royal Jelly acid

Royal Jelly Acid ((E) -Queen Bee Acid) is a major fatty acid found in royal jelly with oral bioavailability, exhibiting anti-inflammatory, anticancer, antimalarial, antiprotozoal, and neuroregulatory activities. Royal Jelly Acid can be used for research in various fields, including cancer, infections, immune inflammation, and neurological diseases[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[14113-05-4]

Product Name Alternative

(E) -Queen Bee Acid; (E) -10-Hydroxy-2-decenoic acid

UNSPSC

12352211

Hazard Statement

H315, H319

Target

Endogenous Metabolite; IFNAR; NF-κB; NO Synthase; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Royal_Jelly_acid.html

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)/C=C/CCCCCCCO

Molecular Formula

C10H18O3

Molecular Weight

186.25

Precautions

H315, H319

References & Citations

[1]Weiser MJ, et al. Long-Term Administration of Queen Bee Acid (QBA) to Rodents Reduces Anxiety-Like Behavior, Promotes Neuronal Health and Improves Body Composition. Nutrients. 2017 Dec 23;10 (1) .|[2]Sugiyama T, et al. Royal jelly acid, 10-hydroxy-trans-2-decenoic acid, as a modulator of the innate immune responses. Endocr Metab Immune Disord Drug Targets. 2012 Dec;12 (4) :368-76.|[3]Sugiyama T, et al. Inhibitory mechanism of 10-hydroxy-trans-2-decenoic acid (royal jelly acid) against lipopolysaccharide- and interferon-β-induced nitric oxide production. Inflammation. 2013 Apr;36 (2) :372-8.|[4]Alkhaibari AM, et al. Insecticidal, Antimalarial, and Antileishmanial Effects of Royal Jelly and Its Three Main Fatty Acids, trans-10-Hydroxy-2-decenoic Acid, 10-Hydroxydecanoic Acid, and Sebacic Acid. Evid Based Complement Alternat Med. 2022 Jan 20;2022:7425322.|[5]Ali A M, et al. The effects of royal jelly acid, 10-hydroxy-trans-2-decenoic acid, on neuroinflammation and oxidative stress in astrocytes stimulated with lipopolysaccharide and hydrogen peroxide[J]. Immuno, 2021, 1 (3) : 212-222.|[6]Shahla J, et al. Comparative immunomodulatory effects of jelly royal and 10-H2DA on experimental autoimmune encephalomyelitis[J]. Gene Reports, 2021, 24: 101217.|[7]Jenkhetkan W, et al. Antiproliferative and cytotoxic efficacy of 10-hydroxy-2-decenoic acid, compared to doxorubicin, on MCF-7 breast cancer cells[J]. Trends in Sciences, 2021, 18 (21) : 409-409.