N- (Azido-PEG4) -N-Boc-PEG4-NHS ester

N- (Azido-PEG4) -N-Boc-PEG4-NHS ester is a PEG-based PROTAC linker with a terminal azide group. N- (Azido-PEG4) -N-Boc-PEG4-NHS ester is used in the synthesis of PROTACs[1] N- (Azido-PEG4) -N-Boc-PEG4-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[2112731-96-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-azido-peg4-n-boc-peg4-nhs-ester.html

Purity

97.0

Solubility

10 mM in DMSO

Smiles

O=C(OC(C)(C)C)N(CCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O

Molecular Formula

C28H49N5O13

Molecular Weight

663.71

Precautions

H302, H315, H319, H335

References & Citations

[1]Kanazaki K, et al. Feasibility of poly (ethylene glycol) derivatives as diagnostic drug carriers for tumor imaging. J Control Release. 2016 Mar 28;226:115-23.