Tirasemtiv
Tirasemtiv is an activator of the fast skeletal muscle troponin complex. Tirasemtiv is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
[1005491-05-3]
Product Name Alternative
CK-2017357
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Tirasemtiv.html
Purity
99.90
Solubility
DMSO : 10.91 mg/mL (ultrasonic)
Smiles
O=C1N(C(CC)CC)C2=NC(C#C)=CN=C2N1
Molecular Formula
C12H14N4O
Molecular Weight
230.27
Precautions
H302, H315, H320, H335
References & Citations
[1]Hwee DT, et al. Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model. PLoS One. 2014 May 7;9 (5) :e96921.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Curated Selection
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