Aβ42 agonist-1

Aβ42 agonist-1 is a compound that can promote Aβ42 aggregation. Aβ42 agonist-1 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-1 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells[1].

Product Specifications

CAS Number

[50635-12-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/aβ42-agonist-1.html

Purity

99.90

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=CC2=C(C=CC=C2)O1)NC3=CC=CC=C3

Molecular Formula

C15H11NO2

Molecular Weight

237.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhao Y et al. Small Molecules N-Phenylbenzofuran-2-carboxamide and N-Phenylbenzo[b]thiophene-2-carboxamide Promote Beta-Amyloid (Aβ42) Aggregation and Mitigate Neurotoxicity. ACS Chem Neurosci. 2023 Nov 16.