L-685458
L-685458 is a potent transition state analog (TSA) γ-secretase inhibitor (GSI) . L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimer’s disease (AD) and cancers[1][2].
Product Specifications
CAS Number
[292632-98-5]
Product Name Alternative
L-685,458
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; γ-secretase
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/L-685458.html
Purity
99.48
Solubility
DMSO : 83.3 mg/mL (ultrasonic; warming)
Smiles
O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)C[C@@H](O)[C@@H](NC(OC(C)(C)C)=O)CC3=CC=CC=C3)=O)=O
Molecular Formula
C39H52N4O6
Molecular Weight
672.85
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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