Taladegib

Taladegib (LY2940680) is an antagonist of the smoothened receptor.

Product Specifications

CAS Number

[1258861-20-9]

Product Name Alternative

LY2940680

UNSPSC

12352005

Hazard Statement

H301, H311, H331

Target

Smo

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ly2940680.html

Purity

99.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CN1N=CC=C1C2=C3C(C=CC=C3)=C(N=N2)N4CCC(CC4)N(C)C(C5=C(C=C(C=C5)F)C(F)(F)F)=O

Molecular Formula

C26H24F4N6O

Molecular Weight

512.50

Precautions

H301, H311, H331

References & Citations

[1]Fraveto A, et al, Sensitivity of Human Intrahepatic Cholangiocarcinoma Subtypes to Chemotherapeutics and Molecular Targeted Agents: A Study on Primary Cell Cultures. PLoS One. 2015 Nov 16;10 (11) :e0142124.|[2]Hoch L, et al. MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor. FASEB J. 2015 May;29 (5) :1817-29.|[3]Ma W, et al. Reduced Smoothened level rescued Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease. J Genet Genomics. 2018 May 20;45 (5) :237-246.