Taladegib
Taladegib (LY2940680) is an antagonist of the smoothened receptor.
Product Specifications
CAS Number
1258861-20-9
Product Name Alternative
LY2940680
UNSPSC
12352005
Hazard Statement
H301, H311, H331
Target
Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ly2940680.html
Purity
99.92
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CN1N=CC=C1C2=C3C(C=CC=C3)=C(N=N2)N4CCC(CC4)N(C)C(C5=C(C=C(C=C5)F)C(F)(F)F)=O
Molecular Formula
C26H24F4N6O
Molecular Weight
512.50
Precautions
H301, H311, H331
References & Citations
[1]Fraveto A, et al, Sensitivity of Human Intrahepatic Cholangiocarcinoma Subtypes to Chemotherapeutics and Molecular Targeted Agents: A Study on Primary Cell Cultures. PLoS One. 2015 Nov 16;10 (11) :e0142124.|[2]Hoch L, et al. MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor. FASEB J. 2015 May;29 (5) :1817-29.|[3]Ma W, et al. Reduced Smoothened level rescued Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease. J Genet Genomics. 2018 May 20;45 (5) :237-246.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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