PAO-Nap
PAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker. PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase[1].
Product Specifications
CAS Number
1613402-20-2
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pao-nap.html
Solubility
10 mM in DMSO
Smiles
O[As](C1=CC=C(NC(CCCCCN(C(C2=CC=C(N)C3=CC=CC4=C23)=O)C4=O)=O)C=C1)O
Molecular Formula
C24H24AsN3O5
Molecular Weight
509.39
References & Citations
[1]Yaping Liu, et al. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase. J Med Chem. 2014 Jun 26;57 (12) :5203-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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