ADX61623
ADX61623 is a potent follicle stimulating hormone (FSH) receptor (FSHR) negative allosteric modulator (NAM) . ADX61623 shows luteinizing hormone receptor (LH-R) activity and is not active on thyroid-stimulating hormone (TSH) receptors. ADX61623 can be used for the study of estrogen dependent disease[1].
Product Specifications
CAS Number
1067189-44-9
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/adx61623.html
Purity
98.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC(C)(C)C1=CC=C(NC(C2=CC=C(C(OC)=C2)OC)=O)C=C1
Molecular Formula
C19H20N2O3
Molecular Weight
324.37
References & Citations
[1]James A Dias, et al. A negative allosteric modulator demonstrates biased antagonism of the follicle stimulating hormone receptor. Mol Cell Endocrinol. 2011 Feb 20;333 (2) :143-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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