Procion Blue HB

Procion Blue HB (Reactive Blue 2) is a purinergic antagonist.

Product Specifications

CAS Number

[12236-82-7]

Product Name Alternative

Reactive Blue 2

UNSPSC

12171500

Hazard Statement

H315, H319

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Procion_Blue_HB.html

Purity

97.93

Solubility

DMSO : ≥ 110 mg/mL|Ethanol : < 1 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)

Smiles

O=S(C(C(N)=C1C2=O)=CC(NC3=CC=C(NC4=NC(Cl)=NC(NC5=CC=CC(S(=O)(O)=O)=C5)=N4)C(S(=O)(O)=O)=C3)=C1C(C6=C2C=CC=C6)=O)(O)=O.O=S(C(C(N)=C7C8=O)=CC(NC9=CC=C(NC%10=NC(Cl)=NC(NC%11=CC=C(S(=O)(O)=O)C=C%11)=N%10)C(S(=O)(O)=O)=C9)=C7C(C%12=C8C=CC=C%12)=O)(O)=O

Molecular Formula

C29H20ClN7O11S3

Molecular Weight

774.16

Precautions

H315, H319

References & Citations

[1]Okuda A, et al. Reactive blue 2 induces calcium oscillations in HeLa cells. Jpn J Physiol. 2001 Jun;51 (3) :389-93.|[2]Lee JH, et al. Reactive blue 2, an antagonist of rat P2Y4, increases K+ secretion in rat cochlea strial marginal cells. Hear Res. 2006 Sep;219 (1-2) :66-73.|[3]Coughlan SJ, et al. Reactive blue 2 is a potent inhibitor of a thylakoid protein kinase. Eur J Biochem. 1991 Apr 23;197 (2) :467-71.|[4]Burnstock G, et al. P2-purinoceptors of two subtypes in the rabbit mesenteric artery: reactive blue 2 selectively inhibits responses mediated via the P2y-but not the P2x-purinoceptor. Br J Pharmacol. 1987 Feb;90 (2) :383-91.|[5]Uneyama H, et al. Suramin and reactive blue 2 are antagonists for a newly identified purinoceptor on rat megakaryocyte. Br J Pharmacol. 1994 Jan;111 (1) :245-9.