NMS-P118
NMS-P118 is a potent, orally available, and highly selective PARP-1 Inhibitor for cancer therapy.
Product Specifications
CAS Number
[1262417-51-5]
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NMS-P118.html
Purity
99.54
Solubility
DMSO : 16 mg/mL (ultrasonic; warming)
Smiles
FC(CC1)(F)CCC1N(CC2)CCC2N(C3=O)CC4=C3C(C(N)=O)=CC(F)=C4
Molecular Formula
C20H24F3N3O2
Molecular Weight
395.42
References & Citations
[1]Papeo G, et al. Discovery of 2-[1- (4,4-Difluorocyclohexyl) piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118) : A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy. J Med Chem. 2015 Sep 10;58 (17) :6875-98.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP2
Available Sizes
Curated Selection
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