NMS-P118

NMS-P118 is a potent, orally available, and highly selective PARP-1 Inhibitor for cancer therapy.

Product Specifications

CAS Number

[1262417-51-5]

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NMS-P118.html

Purity

99.54

Solubility

DMSO : 16 mg/mL (ultrasonic; warming)

Smiles

FC(CC1)(F)CCC1N(CC2)CCC2N(C3=O)CC4=C3C(C(N)=O)=CC(F)=C4

Molecular Formula

C20H24F3N3O2

Molecular Weight

395.42

References & Citations

[1]Papeo G, et al. Discovery of 2-[1- (4,4-Difluorocyclohexyl) piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118) : A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy. J Med Chem. 2015 Sep 10;58 (17) :6875-98.