Thalidomide-piperazine-Boc
Thalidomide-piperazine-Boc is an intermediate that can be used in the synthesis of B-cell lymphoma 6 protein (BCL6) PROTAC[1].
Product Specifications
CAS Number
[2222114-64-7]
UNSPSC
12352005
Hazard Statement
H301, H312, H361
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-piperazine-boc.html
Purity
98.82
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(C2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)CC1)OC(C)(C)C
Molecular Formula
C22H26N4O6
Molecular Weight
442.47
Precautions
H301, H312, H361
References & Citations
[1]Michael Berlin, et al. Bifunctional molecules containing an e3 ubiquitine ligase binding moiety linked to a bcl6 targeting moiety. WO2021077010A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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