Levobupivacaine (hydrochloride)

Levobupivacaine hydrochloride ((S) - (-) -Bupivacaine monohydrochloride) is a long-acting amide local agent that can suppress or relieve pain. Levobupivacaine hydrochloride exerts agent that can suppress or relieve pain. and analgesic effects through reversible blockade of neuronal sodium channel. Levobupivacaine hydrochloride can inhibit impulse transmission and conduction in cardiovascular and other tissues, possessing certain cardiac and CNS toxicity. Levobupivacaine hydrochloride is metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo. Levobupivacaine hydrochloride can also induce ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer[1][2][3].

Product Specifications

CAS Number

[27262-48-2]

Product Name Alternative

(S) - (-) -Bupivacaine monohydrochloride

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Ferroptosis; Sodium Channel

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel

Field of Research

Neurological Disease; Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Levobupivacaine-hydrochloride.html

Purity

99.86

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C([C@H]1N(CCCC)CCCC1)NC2=C(C)C=CC=C2C.[H]Cl

Molecular Formula

C18H29ClN2O

Molecular Weight

324.89

Precautions

H315, H319, H335

References & Citations

[1]Sanford M, et al. Levobupivacaine: a review of its use in regional anaesthesia and pain management. Drugs. 2010 Apr 16;70 (6) :761-91.|[2]Mao SH, et al. Levobupivacaine Induces Ferroptosis by miR-489-3p/SLC7A11 Signaling in Gastric Cancer. Front Pharmacol. 2021 Jun 9;12:681338.|[3]Marganella C, et al. Comparative effects of levobupivacaine and racemic bupivacaine on excitotoxic neuronal death in culture and N-methyl-D-aspartate-induced seizures in mice. Eur J Pharmacol. 2005 Aug 22;518 (2-3) :111-5.