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L-Homopropargylglycine

Selected Variant

HY-140345-01

Size: 5 mg

L-Homopropargylglycine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor[1][2].

Product Specifications

CAS Number

98891-36-2

UNSPSC

12352211

Hazard Statement

H242

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/l-homopropargylglycine.html

Purity

98.0

Solubility

H2O : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C#CCC[C@H](N)C(O)=O

Molecular Formula

C6H9NO2

Molecular Weight

127.14

Precautions

H242

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562|[2]Shen Y, et al. Protocol for visualizing newly synthesized proteins in primary mouse hepatocytes. STAR Protoc. 2021;2 (3) :100616. Published 2021 Jun 17.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Alkyl-Chain Linkers

Available Sizes

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